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Literature

Literature of Intrahepatic Cholestasis of Pregnancy

Published literature

Review articles

Geenes V, Williamson C: Intrahepatic Cholestasis of pregnancy. World J Gastro 2009;15:2049-2066. [Pub Med]

Pusl T, Beuers U: Intrahepatic cholestasis of pregnancy. Orphanet J Rare Diseases 2007;2:26. [Pub Med]

Symptoms

Berg B, Helm G, Petersohn L, Tryding N: Cholestasis of pregnancy. Clinical and laboratory studies. Acta Obstet Gynecol Scand 1986;65:107-113. [Pub Med]

Kenyon et al. Pruritus may precede abnormal liver function tests in pregnant women with obstetric cholestasis: a longitudinal analysis. Br J Obstet Gynaec 2001;108:1190-1192. [Pub Med]

Kremer AE, Martens JJWW, Kulik W, et al: Lysophosphatidic acid is a potential mediator of cholestatic pruritis. Gastroeneterology 2010;139:1008-1018. [Pub Med]

Reyes et al. Steatorrhea in patients with intrahepatic cholestasis of pregnancy. Gastroenterology 1987;93:584-590. [Pub Med]

Etiology

Hirvioja ML, Kivinen S: Inheritance of intrahepatic cholestasis of pregnancy in one kindred. Clinical Genetics 1993;43:315- 317 [Pub Med]

Dixon PH, Wadsworth CA, Chambers J, et al: A Comprehensive Analysis of Common Genetic Variation Around Six Candidate Loci for Intrahepatic Cholestasis of Pregnancy. Am J Gastro 2014;109:76-84 [Pub Med]

Savander M, Rapponen A, Avela K, et al: Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy. Gut 2003;52:1025-1029 [Pub Med]

Keitel V, Vogt C, Haussinger D, Kubitz R: Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy. Gastroenterology 2006;131:624-629. [Pub Med]

Johnston RC, Stephenson ML, Nageotte MP: Novel heterozygous ABCB4 gene mutation causing recurrent first-trimester intrahepatic cholestasis of pregnancy. J Perinat 2014;34:711-712 [Pub Med]

Drug- and Estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver [Pub Med]

Bacq Y, Sapey T, Brechot MC, et al: Intrahepatic cholestasis of pregnancy: a French prospective study. Hepatology 1997;26:358-364 [Pub Med]

Bacq Y, Myara A, Brechot MC, et al: Serum conjugated bile acid profile during intrahepatic cholestasis of pregnancy. Journal of Hepatology 1995;22:66-70 [Pub Med]

Abu-Hayyeh S, Ovadia C, Lieu T, et al: Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritis gravidarum. Hepatology, 2015;doi:10.1002/hep.28265 [Pub Med]

Pacella G, Salsi G, Archangeli T, et al: The impact of assisted reproductive technology and chorionicity in twin pregnancies complicated by obstetric cholestasis. J Matern Fetal Neonatal Med, 2015; doi:10.3109/14767058.2015.1051954 [Pub Med]

Gonzalez MC, Reyes J, Arrese M, et al: Intrahepatic cholestasis of preganancy in twin pregnancies. J Hepatology 1989;9:84-90 [Pub Med]

Reyes H, Maez ME, Gonzalez MC, et al: Selenium, zinc and copper plasma levels in intrahepatic cholestasis of pregnancy, in normal pregnancies and in healthy individuals, in Chile. J Hepatology 2000;32:542-549 [Pub Med]

Floreani A, Caroli D, Lazzari R et al: Intrahepatic cholestasis of pregnancy: new insights into its pathogenesis. J Matern Fetal Neonatal Med 2013;26(14):1410-1415. [Pub Med]

Diagnosis

Lee RH, Ouzounian JG, Goodwin TM, et al: Bile acid concentration reference ranges in a pregnant Latina population. Am J Perinatology 2013;30(5):389-393. [Pub Med]

Understanding Intrahepatic Cholestasis of Pregnancy – Publications SMFM.org – The Society for Maternal-Fetal Medicine. Smfmorg. 2015. Available at: https://www.smfm.org/publications/96-understanding-intrahepatic-cholestasis-of-pregnancy.

Maternal complications

Reid R, Ivey KJ, Rencoret RH, Storey B: Fetal complications of obstetric cholestasis. Br Medical J 1976;1:870-872. [Pub Med]

DeLeon A, De Oliveira GS, Kalayil M et al: The incidence of coagulopathy in pregnant patients with intrahepatic cholestasis: should we delay or avoid neuraxial analgesia? J Clinical Anesthesia 2014;26(8):623-627. [Pub Med]

Ranier PP, Primessniq U, Harencamp S, et al: Bile acids induce arrhythmias in human atrial myocardium–implications for altered serum bile acid composition in patients with atrial fibrillation. Heart 2013;99(22):1685-1692. [Pub Med]

Biberoglu EH, Kirbas A, Kirbas O, et al: Prediction of cardiovascular risk by by electrocardiographic changes in women with intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med 2015;28(18):2239-2243. [Pub Med]

Fetal complications

Wikstrom SE, Marschall HU, Ludvigsson JF, Stephansson O: Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study. Br J Obstet Gynaec 2013;120:717-723. [Pub Med]

Fisk NM, Storey GN: Fetal outcome in obstetric cholestasis. Br J Obstet Gynaec 1988;95:1137-1143. [Pub Med]

Davies MH, Silva RCMA, Jones SR et al: Fetal mortality associated with cholestasis of pregnancy and the potential benefit of therapy with ursodeoxycholic acid. Gut 1995;37:580-584. [Pub Med]

Glantz A, Marschall HU, Mattsson LA: Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates. Hepatology 2004;40:467-474. [Pub Med]

Related editorials:
Egerman RS, Riely CA: Predicting fetal outcome in intrahepatic cholestasis of pregnancy: Is the bile acid level sufficient? Hepatology 2004;40(2):287-288. [Wiley Online] Sentilhes L, Verspyck E, Roman H, Marpeau L: Intrahepatic cholestasis of pregnancy and bile acid levels. Recoret R, Aste H: Jaundice during pregnancy. Med J Australia. 1973;1:167-169. [Pub Med]

Madazli R, Yuksel MA, Oncul M: Pregnancy outcomes and prognostic factors in patients with intrahepatic cholestasis of pregnancy. J Obstet Gynaec. 2015;35(4). [Pub Med]

Geenes V, Chappell, LC, Seed PT, et al: Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study. Heptatology. 2014;59(4):1482-1491. [Pub Med]

Brouwers L, Koster MPH, Page-Christiaens GCML, et al: Intrahepatic cholestasis of pregnancy: maternal and fetal outcomes associated with elevated bile acids. Am J Obstet Gynec 2015;212(1);100.e1-100.e7. [Pub Med]

Additional comments by the author (http://www.ajog.org/article/S0002-9378(15)00322-1/fulltext)

Germain AM, Kato S, Carvajal JA, et al: Bile acids increase response and expression of human myometrial oxytocin receptor. Am J of Obstet Gynecol 2003;189:577-582. [Pub Med]

Kawakita T, Parikh LI, Ramsey PS, et al: Predictors of adverse neonatal outcomes in intrahepatic cholestasis of pregnancy. Am J Obstet Gynec. 2015;213(4):570.e1-570.e2. [Pub Med]

Rook M, Vargas J, Caughey A, et al: Fetal outcomes in pregnancies complicated by intrahepatic cholestasis of pregnancy in a Northern California cohort. PLoS ONE 2012;7: e28343. [Pub Med]

Zecca E, De Luca D, Marras M, et al: Intrahepatic cholestasis of pregnancy and neonatal respiratory distress syndrome. Pediatrics 2006;117:1669-1673. [Pub Med]

Kowalski A, Janosz-Galdys I, Olejek A, et al: Correlation between serum levels of bile acids in pregnant women with intrahepatic cholestasis of pregnancy and condition of their newborns. Ginekol Pol 2014;85(2):101-104. [Pub Med]

Zecca E, De Luca D, Barbato, G, et al: Predicting respiratory distress syndrome in neonates from mothers with intrahepatic cholestasis of pregnancy. Early Human Development 2008;84:337-341. [Pub Med]

Oztekin D, Aydal I, Oztekin O, et al: Predicting fetal asphyxia in intrahepatic cholestasis of pregnancy. Archives Gynecol Obstet 2009;280:975-979. [Pub Med]

Hepatology 2005;42(3):737-738. [Wiley Online]

Zecca E, Costa S, Lauriola V, et al: Bile acid pneumonia: A “new” form of neonatal respiratory distress syndrome? Pediatrics 2003;114:269-272. [Pub Med]

Zecca E, De Luca D, Baroni S, et al: Bile acid-induced injury in newborn infants: a bronchoalveolar study. Pediatrics 2008;121:e146-149. [Pub Med]

Herraez E, Lozano E, Poli E, et al: Role of macrophages in bile acid-induced inflammatory response of fetal lung during maternal cholestasis. J Molec Medicine 2014;92(4):359-372. [Pub Med]

Shaw D, Frohlich J, Wittmann BA, Willms M: A prospective study of 18 patients with cholestasis of pregnancy. Am J Obstet Gynecol 1982;142:621-625. [Pub Med]

Sheibani L, Urinak ABS, Lee RH et al: Intrahepatic cholestasis of pregnancy: the effect of bile acids on fetal heart rate tracings. Obstet Gynec 2014;123:78S-79S. [Research Gate]

Williamson C, Miragoli M, Kadir SSA et al: Bile acid signaling in fetal tissues: implications for intrahepatic cholestasis of pregnancy. Digestive Diseases 2011;29:58-61. [Pub Med]

Sepulveda WH, Gonzalez C, Cruz MA, Rudolph MI et al: Vasoconstrictive effect of bile acids on isolated human placental chorionic veins. Eur J Obstet Gynec Reprod Biol 1991;42(3):211-215. [Pub Med]

Shemer EW, Thorsell M, Ostlund E, et al: Stereological assessment of placental morphology in intrahepatic cholestasis of pregnancy. Placenta 2012;33:914-918. [Pub Med]

Geenes VL, Lim YH, Bowman N, et al: A placental phenotype for intrahepatic cholestasis of pregnancy. Placenta 2011;32: 1026-1032. [Pub Med]

Oztas E, Ozler S, Ersoy AO et al: Placental ADAMTS-12 levels in the pathogenesis of preeclampsia and intrahepatic cholestasis of pregnancy. Reproductive Sciences 2015;doi:10.1177/193371 115604730 [Pub Med]

Martineau M, Papcleovoulou G, Abu-Hayyeh SA et al: Cholestatic pregnancy is associated with reduced placental 11βHSD2 expression. Placenta 2014;35(1):37-43. [Pub Med]

Sudden fetal death despite reassuring CTG

Lee RH, Incerpi MH, Miller D, et al: Sudden fetal death in intrahepatic cholestasis of pregnancy. Obstet Gynecol 2009;113:528-531. [Pub Med]

Laatikainen T, Tulenheimo A: Maternal serum bile acid levels and fetal distress in cholestasis of pregnancy. Internat J Gynaecol Obstet 1984;22:91-94. [Pub Med]

Alsulyman OM, Ouszounian JG, Ames-Castro M, Goodwin TM: Intrahepatic cholestasis of pregnancy: perinatal outcome associated with expectant management. Am J Obstet Gynecol 1996;175:957-960. [Pub Med]

Sentilhes L, Verspyck E, Pia P, Marpeau L: Fetal death in a patient with intrahepatic cholestasis of pregnancy. Obstet Gynecol 2006;107:458-460. [Pub Med]

Management

Bacq Y, Sentilhes L, Reyes HB, et al: Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis. Gastroenterology 2012;143:1492-1501. [Pub Med]

Lee RH, Kwok KM, Ingles S, et al: Pregnancy outcomes in an era of aggressive management for intrahepatic cholestasis of pregnancy. Am J Perinatology 2008;25:341-345. [Pub Med]

Roncaglia N, Arreghini A, Locatelli A, et al: Obstetric cholestasis: outcome with active management. Eur J Obstet Gynecol Reprod Biol. 2002;100(2):167-170. [Pub Med]

Mays JK: The active management of intrahepatic cholestasis of pregnancy. Current Opinion Obstet Gynecol 2010;22:100-108. [Pub Med]

Henry A, Welsh AW: Monitoring intrahepatic cholestasis of pregnancy using the fetal myocardial performance index: a cohort study. Ultrasound Obstet Gynecol 2015;46:571-578. [Pub Med]

Carey E, White P: Ursodeoxycholic acid for intrahepatic cholestasis of pregnancy: good for the mother, not bad for the baby. Evid Based Med 2013;18(6):e55. [Pub Med]

Grand’Maison S, Durand M, Mohone M: The effects of Ursodeoxycholic acid treatment for intrahepatic cholestasis of pregnancy on maternal and fetal outcomes: a meta-analysis including non-randomized studies. J Obstet Gynaec Can 2014;36(7):632-641. [Pub Med]

Serrano MA, Brites D, Larena MG, et al: Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta. J Hepatology 1998;28:829-839. [Pub Med]

Geenes V, Lovgren-Sandblom A, Benthin L, et al: The reversed feto-maternal bile acid gradient in intrahepatic cholestasis of pregnancy is corrected by ursodeoxycholic acid. Plos One 2014;9(1):e83828. [Pub Med]

Azzaroli F, Raspanti ME, Simoni P, et al: High doses of ursodeoxycholic acid up-regulate the expression of placental breast cancer resistance protein in patients affected by intrahepatic cholestasis of pregnancy. Plos One 2013;8:e64101. [Pub Med]

Estiu MC, Monte MJ, Rivas L: Effect of ursodeoxycholic acid on the altered progesterone and bile acid homeostasis in the mother-placenta-foetus trio during cholestasis of pregnancy. Br J Clinical Pharm 2015;79(2):316-329. [Pub Med]

Paumgartner G, Beuers U: Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited. Hepatology 2002;36:525-531. [Pub Med]

Geenes V, Chambers J, Khurana R: Rifampicin in the treatment of severe intrahepatic cholestasis of pregnancy. Eur J Obstet Gynecol Reprod Biol 2015;189:59-63. [Pub Med]

Nicastri PL, Diaferia A, Tartagni M, et al: A randomized placebo-controlled trial of ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy. Br J Obstet Gynaecol 1998;105(11):1205-1207. [Pub Med]

Heikkinen J, Maentausta O, Ylostalo P, et al: Serum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramine. Eur J Obstet Gynec Reprod Biol 1982;14:153-162. [Pub Med]

ACOG.org: Nonmedically indicated early-term deliveries – ACOG 2015. (See Box 1 for medical indications, including ICP)

Davies MH, Silva RCMA, Jones SR et al: Fetal mortality associated with cholestasis of pregnancy and the potential benefit of therapy with ursodeoxycholic acid. Gut 1995;37:580-584. [Pub Med]

Puljic A, Kim E, Page J, et al: The risk of infant and fetal death by each additional week of expectant management in intrahepatic choelstasis of pregnancy by gestational age. Am J Obstet Gynecol 2015;212(5):667.e1-5. [Pub Med]

Lo JO, Shaffer BL, Allen AJ, et al: Intrahepatic cholestasis of pregnancy and timing of delivery. J Matern Fetal Neonatal Med 2015;28(18):2254-2258. [Pub Med]

Liu X, Landon MB, Chen Y, and Cheng W: Perinatal outcomes with intrahepatic cholestasis of pregnancy in twin pregnancies. J Matern Fetal Neonatal Med 2015;doi:10.3109/14767058.2015.1079612. [Pub Med]

Bull L,Vargas J: Serum bile acids in intrahepatic cholestasis of pregnancy: not just a diagnostic test. Hepatology 2014;59(4):1220-1222. [Pub Med]

Concurrent complications

Martineau M, Raker C, Powrie R, Williamson C: Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes. Eur J Obstet Gynecol Reprod Biol 2014;176:80-85. [Pub Med]

Raz Y, Lavie A, Vered Y, et al: Severe intrahepatic cholestasis of pregnancy is a risk factor for preeclampsia in singleton and twin pregnancies. Am J Obstet Gynecol 2015;213(3)395.e1-395.e8 [Pub Med]

Follow up care

Aytac S, Kargili A, Turaky C: A prolonged gestational intrahepatic cholestasis: a case report. Turk J Gastroenterology 2006;17:206-208. [Pub Med]

Hardikar W, Kansal S, Elferink RPJO, Angus P: Intrahepatic cholestasis of pregnancy: when should you look further? World J Gastroent 2009;15:1126-1129. [Pub Med]

Ropponen A, Sund R, Riikonen S, et al: Intrahepatic Cholestasis of Pregnancy as an Indicator of Liver and Biliary Diseases: a Population-Based Study. Hepatology 2006;43:723-729. [Pub Med]

Serge E: Intrahepatic cholestasis of pregnancy: A risk factor for cancer, autoimmune and cardiovascular disease? Clinical Research Hep Gastro 2015;doi:10.1016/j.clinre.2015.09.003 [Pub Med]

Papacleovoulou G, Abu-Hayyeh S, Nikolopoulou E, et al: Maternal cholestasis during pregnancy programs metabolic disease in offspring. J Clinic Invest 2013;123(7):3172-3181. [Pub Med]

Vimpeli T, Turunen K, Helander K, et al: Mother’s intrahepatic cholestasis does not affect her daughter’s health. Health 2013;5(6A):28-33. [SCRIP]

Hamalainen S, Turunen K, Kosunen E, et al: Men’s health is not affected by their mother’s intrahepatic cholestasis of pregnancy. Am J Men’s Health 2015;pii:1557988315584795. [Pub Med].